Key result
Highest BP variability tertile linked to ~69% greater dementia risk vs the lowest tertile.
Why the study?
Does higher blood pressure variability increase the risk of probable dementia or mild cognitive impairment in participants of the SPRINT MIND trial?
Cohort
Does higher blood pressure variability increase the risk of probable dementia or mild cognitive impairment in participants of the SPRINT MIND trial?
Effect estimate: HR 1.69 (95% CI 1.25-2.28)
Higher blood pressure variability is associated with an increased risk of developing probable dementia, even in the setting of excellent blood pressure control.
BP variability was associated with dementia despite intensive control; hypothesis-generating and requires prospective trials before changing practice.
<0.001). In the Cox models, compared with the lowest tertile of BPV, the highest tertile of BPV increased the risk of dementia in both unadjusted (hazard ratio [HR], 2.36; 95% CI, 1.77-3.15) and adjusted (HR, 1.69; 95% CI, 1.25-2.28) models. Conclusions In a post hoc analysis of the SPRINT MIND trial, we found that higher BPV was associated with the development of probable dementia despite excellent blood pressure control. Additional research is needed to understand how to reduce BPV and if its reduction lowers the risk of cognitive impairment and dementia.
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Havenon et al. (2021) conducted a cohort in Probable dementia or mild cognitive impairment. Highest tertile of blood pressure variability (BPV) vs. Lowest tertile of BPV was evaluated on Dementia (HR 1.69, 95% CI 1.25-2.28). The highest tertile of blood pressure variability was associated with an increased risk of dementia compared with the lowest tertile (adjusted HR 1.69; 95% CI 1.25-2.28).
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