Answers are grounded in this paper and cite their sources.
BACKGROUND: Diagnosis of extrapulmonary tuberculosis continues to be a challenge due to the complexity of the causative organism and the wide array of pathologic features seen in this infection. Xpert MTB/RIF can be used on fresh or frozen tissue specimens for diagnosis of tuberculosis with good results. However, there is little data on its use with formalin-fixed paraffin-embedded (FFPE) tissues. OBJECTIVES: from FFPE tissues using histological features from haematoxylin and eosin staining as the gold standard. METHODS: MTB/RIF assay. The outcome measures were proportions of positively identified cases by each test. None of the cases tested positive for rifampicin resistance. CONCLUSION: MTB/RIF assay. A validation study to determine the clinical utility, analytical optimisation and cost implications of this assay for FFPE tissues is recommended.
No takes yet. Share an insight, caveat, or question.
Njau et al. (2019) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: