Key result
High plasma-free haemoglobin at sternal closure is linked to worse three-month cognitive performance.
Why the study?
Do neuronal damage biomarkers identify patients at risk of long-term postoperative cognitive dysfunction after cardiac surgery?
Observational
Do neuronal damage biomarkers identify patients at risk of long-term postoperative cognitive dysfunction after cardiac surgery?
Plasma-free haemoglobin at sternal closure, but not classical neuronal injury biomarkers, may help identify patients at risk for long-term cognitive decline after cardiac surgery.
Answers are grounded in this paper and cite their sources.
Plasma-free haemoglobin may flag cognitive risk after cardiac surgery but should not yet change practice; leaves open validation versus neuronal biomarkers in prospective cohorts.
in patients without cognitive dysfunction. This biomarker remained significantly higher in patients with cognitive decline throughout the entire postoperative period. At 3 months after surgery, high levels of plasma-free haemoglobin at sternal closure were associated with a negative influence on cognitive performance, as were high baseline scores on neuropsychological tests, whereas a higher level of education proved to beneficially influence cognitive outcome. We found that postoperative cognitive dysfunction at 3 months was associated with cognitive decline at 15 months after surgery, and served as a valuable prognostic factor for declines in individual cognitive performance one year later. Classical neuronal injury-related biomarkers were of no clear prognostic value.
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Kok et al. (2016) conducted an observational in Postoperative cognitive dysfunction after cardiac surgery. Plasma-free haemoglobin and neuronal damage biomarkers was evaluated on Cognitive performance and postoperative cognitive dysfunction. High levels of plasma-free haemoglobin at sternal closure were associated with negative cognitive performance at 3 months, whereas classical neuronal injury biomarkers had no prognostic value.
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