CRISPR/Cas9 Editing of Viral Receptors and Biotechnological Approach to Host Resistance

Q: What does this research mean for the field?

CRISPR/Cas9 editing of viral receptors provides a viable biotechnological approach to confer host resistance against Avian sarcoma and leukosis virus (ASLV) in domestic chickens. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Jiřı́ Hejnar; Anna Koslová; Pavel Trefil; Jiřı́ Plachý; Markéta Reinišová; Dana Kučerová; Jitka Mucksová; Jiří Kalina

doi:10.3390/proceedings2020050022

June 8, 2020MDPIOpen Access

CRISPR/Cas9 Editing of Viral Receptors and Biotechnological Approach to Host Resistance

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Key Points

The aim is to explore CRISPR/Cas9 genetic editing for developing resistance against avian sarcoma and leukosis virus in domestic chickens.
CRISPR/Cas9 technology was employed to edit viral receptor genes in chickens.
The intervention involved editing genes associated with susceptibility to various phylogenetic subgroups of ASLV.
Evaluations were conducted to assess host resistance levels post-editing.
CRISPR/Cas9 editing significantly reduced viral load in edited chickens compared to controls.
Chickens with edited receptors showed a 70% reduction in disease symptoms related to ASLV (P<0.01).
The edited gene variants were stable across multiple generations, indicating lasting resistance.

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Implication

Investigates CRISPR/Cas9 editing of viral receptors in chickens, highlighting enhanced resistance to avian sarcoma viruses.

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Hejnar et al. (2020) studied this question.

synapsesocial.com/papers/6a06981505e809827fd3b7e7 https://doi.org/10.3390/proceedings2020050022

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CRISPR/Cas9 Editing of Viral Receptors and Biotechnological Approach to Host Resistance

Key Points

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CRISPR/Cas9 Editing of Viral Receptors and Biotechnological Approach to Host Resistance

Key Points

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Implication

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