A premature stop codon within thetvbreceptor gene results in decreased susceptibility to infection by avian leukosis virus subgroups B, D, and E

November 18, 2017OncotargetOpen Access

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Key Points

This research aims to investigate how a premature stop codon in the tvb receptor gene affects susceptibility to avian leukosis viruses.
Genetic analysis of the tvb receptor gene to identify the presence of a premature stop codon.
Assessment of infection susceptibility to avian leukosis virus subgroups B, D, and E.
Comparison of infection rates between individuals with and without the stop codon.
Individuals with the premature stop codon exhibit a significantly lower rate of infection by ALV-B, D, and E compared to those without it.
Specific percentages of infection susceptibility were not detailed but suggest strong resistance.
The findings highlight a genetic basis for increased resistance to these viral infections.

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Demonstrates decreased susceptibility to avian leukosis virus infections in a genetic model, suggesting a potential resistance mechanism.

could potentially serve as a resistant target against ALV-B, ALV-D and ALV-E infection.

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Chen et al. (2017) studied this question.

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