Key result
Avian myosin heavy chain proteins and genes exhibit fundamental properties that are unique among higher vertebrates when compared to those of mammals.
This review highlights that avian myosin heavy chains possess unique properties and genetic regulation compared to mammals, offering insights into their evolutionary mechanisms.
Unique avian myosin properties warrant caution in cross-species cardiac models; leaves open functional implications for human myocardium.
This article reviews the complexity, expression, genetics, regulation, function, and evolution of the avian myosin heavy chain (MyHC). The majority of pertinent studies thus far published have focussed on domestic chicken and, to a much lesser extent, Japanese quail. Where possible, information available about wild species has also been incorporated into this review. While studies of additional species might modify current interpretations, existing data suggest that some fundamental properties of myosin proteins and genes in birds are unique among higher vertebrates. We compare the characteristics of myosins in birds to those of mammals, and discuss potential molecular mechanisms and evolutionary forces that may explain how avian MyHCs acquired these properties.
No takes yet. Share an insight, caveat, or question.
Bandman et al. (2000) conducted a review in Avian myosin heavy chain (MyHC) heterogeneity. Avian myosin heavy chain proteins and genes exhibit fundamental properties that are unique among higher vertebrates when compared to those of mammals.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: