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May 1, 2026American Journal Of PathologyOpen Access

Anti-RANKL improves muscle dysfunction and strengthens bone in laminin-α2-deficient dy2J/dy2J dystrophic mice.

Zineb Bouredji Anthony Facchin Dounia Hamoudi Hideo Yagita Norbert Laroche Marthe Rousseau Anteneh Argaw Jérôme Frenette

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Key Points

The research aims to evaluate the effects of anti-RANKL on muscle dysfunction and bone health in laminin-α2-deficient mice.
Utilized dy2J/dy2J dystrophic mice as a model for the intervention.
Administered anti-RANKL treatment to assess effects on muscle and bone function.
Conducted assessments of muscle force and motor performance, though specifics were not detailed.
Observed improvements in muscle dysfunction and bone strength post anti-RANKL treatment, but not significant enough to enhance absolute muscle force.
Global motor performance remained unaffected, indicating limitations of the treatment.

Implication

Shows improved muscle and bone strength in dystrophic mice, suggesting new treatment options.

Abstract

dystrophic mice, but these improvements were insufficient to enhance absolute muscle force or global motor performance.

Discussion

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Cite This Study

Bouredji et al. (2026) studied this question.

synapsesocial.com/papers/6a06b74ce7dec685947aa474 https://doi.org/10.1016/j.ajpath.2026.04.011

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1RANKL inhibition improves muscle strength and insulin sensitivity and restores bone massOriginal Research · 2019 · 313 citations
2Laminin-111 improves muscle repair in a mouse model of merosin-deficient congenital muscular dystrophypreclinical · 2013 · 61 citations
3Laminin-111 Protein Therapy Reduces Muscle Pathology and Improves Viability of a Mouse Model of Merosin-Deficient Congenital Muscular Dystrophypreclinical · 2012 · 88 citations
4Spatial-proteomics reveals recombinant human laminin-111 restores adhesion-signaling to laminin-α2 deficient muscle2025 · 2 citations
5Treatment with the anti-IL-6 receptor antibody attenuates muscular dystrophy via promoting skeletal muscle regeneration in dystrophin-/utrophin-deficient miceOriginal Research · 2017 · 75 citations

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