Synthesis of 1,4,5,6-Tetrahydropyridazine Derivatives via Tandem Annulation of Coumarin Hydrazones and Bench-Stable Allenyl Sulfonium Salt

Dhinakaran Murali Mohan; Deeksha Balakrishnan; Han-Hsing Huang; Wei‐Min Liu

doi:10.1021/acs.orglett.6c01522

May 12, 2026Organic Letters

Synthesis of 1,4,5,6-Tetrahydropyridazine Derivatives via Tandem Annulation of Coumarin Hydrazones and Bench-Stable Allenyl Sulfonium Salt

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Key Points

This research aims to develop a method for synthesizing fused tricyclic structures from coumarin hydrazones.
Utilized tandem annulation involving coumarin hydrazones and bench-stable allenyl sulfonium salt.
Conducted under mild conditions with a broad substrate range.
Achieved excellent functional-group tolerance in the synthesis process.
Successfully created diverse fused tricyclic structures.

Implication

Tandem annulation enables the synthesis of diverse tricyclic structures with high tolerance in mild conditions.

Abstract

isomerization routes, enabling the synthesis of fused tricyclic structures under mild conditions with a broad substrate range and excellent functional-group tolerance.

Discussion

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Cite This Study

Mohan et al. (2026) studied this question.

synapsesocial.com/papers/6a06b7eae7dec685947aa7d0 https://doi.org/10.1021/acs.orglett.6c01522

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Synthesis of 1,4,5,6-Tetrahydropyridazine Derivatives via Tandem Annulation of Coumarin Hydrazones and Bench-Stable Allenyl Sulfonium Salt

Key Points

Implication

Abstract

Discussion

Cite This Study

Synthesis of 1,4,5,6-Tetrahydropyridazine Derivatives via Tandem Annulation of Coumarin Hydrazones and Bench-Stable Allenyl Sulfonium Salt

Key Points

Implication

Abstract

Discussion

Cite This Study

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