ABSTRACT Colored rice has been reported to contain bioactive compounds. This study investigated the phytochemical composition, antioxidant, antibacterial, anti‐inflammatory, and cytotoxic properties of Oryza sativa L. Cv . MRQ 98 methanolic (M) and acetone (A) extracts, cultivated exclusively in Skuduk‐Chupak, Sarawak, Malaysia. HPLC analysis identified several phenolic acids in both free and bound fraction forms. The DPPH assay showed strong antioxidant activities, with maximal scavenging observed at 10 mg/mL. Anti‐inflammatory activity showed more than 50% protection with extract concentrations lower than 2.5 mg/mL. In contrast, antibacterial activity against Cutibacterium acnes , Staphylococcus aureus , and Staphylococcus epidermidis was weak, with IC 50 exceeding 10 mg/mL. Cytotoxicity evaluation showed more than 90% cell viability at 0.3125–0.625 mg/mL concentrations, decreasing to 77% viability at higher doses. In conclusion, Oryza sativa L. Cv . MRQ 98 extracts exhibited good antioxidant and anti‐inflammatory properties and were nontoxic; hence, their potential use for antiacne applications can further be explored.
Farahanah et al. (Fri,) studied this question.
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