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May 15, 2026The Journal of Organic Chemistry0 citations

Dichloromethane as a C 1 Synthon for Copper-Catalyzed Dual Functionalization of Olefins

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WJWangqin JiYWYing-Ying WeiJZJiyuan Zhou

Key Points

  • This study aims to introduce an efficient method for constructing C-C bonds using dichloromethane as a synthon.
  • Utilized copper-catalyzed dual functionalization of olefins.
  • Applied gram-scale synthesis of noncyclic alkyl chloride products using readily available starting materials.
  • Explored isotopic labeling for deuterium-labeled alkyl chlorides.
  • Successfully constructed C-C bonds with concomitant methylene insertion and chloroalkyl functionalization.
  • Demonstrated versatility and practicality in the synthesis of alkyl chlorides.
  • Highlighted potential applications in organic synthesis and drug discovery.

Abstract

synthon has been established. This method efficiently constructs C-C bonds via concomitant methylene insertion and chloroalkyl functionalization, providing a direct and modular approach for the synthesis of noncyclic alkyl chloride products using simple and readily available starting materials. The practicability of this new approach has been successfully applied at the gram scale. Moreover, this methodology extends to the synthesis of deuterium-labeling alkyl chloride products, highlighting its potential for isotopic labeling and its versatility in organic synthesis and drug discovery.

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Cite This Study

Ji et al. (2026) studied this question.

synapsesocial.com/papers/6a06b8c5e7dec685947ab2eehttps://doi.org/10.1021/acs.joc.6c00440
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