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May 15, 2026Food Science & NutritionOpen Access

Tetrandrine, a Major Alkaloid From Stephaniae Tetrandrae Radix , Ameliorates Non‐Alcoholic Fatty Liver Disease in Zebrafish via the PI3K / AKT / STAT3 Pathway

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Authors

PSPeng SunJWJun WuKMKai Ma

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Overview

Randomized trial demonstrates tetrandrine reduces liver fat in zebrafish, suggesting therapeutic potential for NAFLD.

Key Points

  • This research investigates the effects of tetrandrine on NAFLD and its mechanisms of action.
  • Utilized network pharmacology to identify targets associated with NAFLD
  • Conducted molecular docking and dynamics simulations to assess interactions of tetrandrine and proteins
  • Validated effects in a thioacetamide-induced zebrafish NAFLD model
  • Tetrandrine significantly reduced hepatic lipid accumulation and serum lipid levels (TG, TC, ALT, AST)
  • Activated the PI3K/AKT/STAT3 signaling pathway while inhibiting TP53 and Bax
  • GEO dataset validation supported AKT1 and EGFR as significant regulatory genes

Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/6a06b8c5e7dec685947ab4cdhttps://doi.org/10.1002/fsn3.71814
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