Background: Nowadays, health issues are common due to lifestyle modifications and a lack of body immunity. This study primarily focuses on the putative action of Paerida foetida by using a hydroalcoholic extract for antioxidant and liver disorders. Methods: Antioxidant properties were evaluated by using DPPH radical scavenging assays. An LC-MS study was carried out for the characterization of compounds. Total Phenolic and flavonoid content were estimated using standard methods. Hepatotoxicity was induced in Swiss mice (25-35 g) by a CCl₄ and corn oil (1:1 v/v) mixture at 2 ml/kg. Then they are treated with Paerida foetida (500 gm/kg and 250 mg/kg) hydroalcoholic extract orally for 21 days. Results: Paerida foetida (500mg/kg) extract exhibits a significant preventive action against liver disorders, as evidenced by a significant reduction (p < 0.001) in high serum levels of AST, ALT, ALP, total bilirubin, and total protein content. The phenolic and flavonoid contents in P. foetida are responsible for antioxidant and hepatoprotective activities. The underlying molecule of Paerida foetida is responsible for an effective ameliorator of liver disease changes at the hepatic level (p < 0.001) of MDA, GSH, and SOD. Discussion: Furthermore, hepatological studies of CCl4-induced necrosis cells have shown an effective cell-healing potency by sylimarin and P. foetida (500mg/kg) extract. LC-MS data revealed the presence of Pterostilbene, flavone, Neoagarobiose, Lathosterol, Sitosterol, and many other acidic esters. Conclusion: Finally, it is concluded that the hydroalcoholic extract of Paerida foetida is a valuable therapeutic herb to prevent liver deterioration and also an antioxidant agent due to the presence of the above-mentioned constituents as major compounds, identified by LC-MS in the plant extract.
Jena et al. (2026) studied this question.