ThLaeA functions as a conditional repressor to maintain metabolic homeostasis in Trichoderma hypoxylon

acts as a conditional repressor that counterbalances Thtri5-dependent perturbations to maintain metabolic homeostasis. This work redefines the LaeA paradigm and provides a framework for understanding the context-dependent regulation of secondary metabolism in fungi. IMPORTANCE: strains, while boosting bioactive secondary metabolite production and optimizing fungal cell factories. This study advances fundamental insights into fungal metabolic regulation and provides a rational basis for strain improvement and biotechnological applications in agriculture and industry.