Key result
Lipidomic remodeling links to aortic stenosis severity and yields circulating biomarkers for valve stiffening.
Observational
Lipidomic profiling of human aortic valves identifies specific triglycerides as potential noninvasive biomarkers for tracking the severity of calcific aortic stenosis.
Our study delivers the largest lipidomic analysis of human aortic valves, revealing early metabolic shifts, especially in diacylglycerols and alkyl-lysophosphatidylcholines that closely track hemodynamic severity. By integrating valve tissue and plasma profiles, we identify triglycerides TG 52:4 and TG 54:4 as promising noninvasive candidate biomarkers. These findings clarify lipid-driven mechanisms of calcific aortic stenosis and highlight new opportunities for earlier detection and risk stratification.
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Surendran et al. (2026) conducted an observational in Calcific Aortic Valve Stenosis. Lipidomic remodelling was evaluated on Hemodynamic severity. Lipidomic profiling of human aortic valves identified metabolic shifts in diacylglycerols and alkyl-lysophosphatidylcholines that closely track hemodynamic severity in calcific aortic stenosis.
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