Key result
Novel CABLE-TAVR technique with 4D ICE demonstrates feasibility for antegrade TAVR under conscious sedation.
Why the study?
An antegrade approach to TAVR has become less common due to complexity and complication risks, though using a large-bore sheath to protect the mitral valve has been described.
Case Report (n=1)
Antegrade TAVR using 4D ICE and a novel sheath-flexing technique may be a feasible alternative for high-risk patients with limited vascular access who cannot undergo general anesthesia.
May enable antegrade TAVR in select patients; hypothesis-generating for 4D ICE guidance in complex procedures.
BACKGROUND: An antegrade approach to transcatheter aortic valve replacement (TAVR) has become less common because of the complexity and chance of complication, but use of a large-bore sheath to protect the mitral valve has been described. CASE SUMMARY: We present a 75-year-old patient with severe symptomatic aortic stenosis who underwent antegrade TAVR with 4-dimensional intracardiac echocardiography under conscious sedation. We describe a novel technique using an Edwards Commander Delivery System to flex a large-bore sheath across the mitral valve to protect the atrial septum and mitral valve during valve delivery. DISCUSSION: Patients with limited vascular access for retrograde TAVR and who are not candidates for general anesthesia owing to pulmonary disease can undergo antegrade TAVR under conscious sedation and 4-dimensional intracardiac echocardiography guidance. TAKE-HOME MESSAGE: Our case illustrates an antegrade approach with a novel technique that may be a suitable alternative to TAVR in high-risk patients who otherwise would not be candidates for aortic valve replacement.
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Robin et al. (2026) conducted a case report in Severe symptomatic aortic stenosis (n=1). Antegrade TAVR with 4-dimensional intracardiac echocardiography under conscious sedation using CABLE-TAVR technique was evaluated on Successful antegrade TAVR procedure. Antegrade TAVR using a novel CABLE-TAVR technique with 4-dimensional intracardiac echocardiography under conscious sedation was successfully performed in a 75-year-old patient with severe aortic stenosis.
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