Vape flavoring chemicals and oral fibroblast viability

, which contribute to tissue breakdown. Increased apoptosis, impaired cell survival, and senescence were reported following longer exposure durations. In contrast, menthol and fruit flavors produced moderate responses, while unflavored aerosols showed little toxicity. These results emphasize that flavored e-cigarette products may accelerate oral tissue deterioration, undermining fibroblast health, and limiting the capacity for tissue repair. As flavored aerosol use remains prevalent among the youth, understanding its toxicity is crucial to advancing public health policies and the regulation of vaping products.