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May 15, 2026Organic Chemistry Frontiers1 citations

Modular Multicomponent Cascade Synthesis of Benzobthiophene-Fused N,O-Heterocycles from 1,2-Benzisothiazoles, Benzolactones and Aldehydes

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LLLongzhi LinZhengzhou UniversityJRJie RenZhengzhou University of Light IndustryHCHeying ChenZhengzhou University

Key Points

  • This research aims to develop a new synthetic method for creating benzo[b]thiophene-fused N,O-heterocycles using a modular approach.
  • Developed a metal-free multicomponent cascade reaction
  • Utilized 1,2-benzisothiazoles, benzolactones, and aldehydes as reactants
  • Focus on synthesizing seven- and eight-membered heterocycles
  • Successfully synthesized new benzo[b]thiophene-fused compounds
  • Demonstrated potential for diverse synthetic applications
  • Showcased the advantages of a modular, metal-free approach

Abstract

A modular, metal-free multicomponent cascade reaction for the synthesis of benzo bthiophene-fused seven-, or eightmembered N,O-heterocyclic compounds from 1,2-benzisothiazoles, benzolactones, and aldehydes has been developed. Notably, 1,2-benzisothiazoles were employed as...

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Cite This Study

Lin et al. (2026) studied this question.

synapsesocial.com/papers/6a06b9e2e7dec685947ac88ahttps://doi.org/10.1039/d6qo00413j
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