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May 15, 20260 citations

Simplified UNICORN for Transcatheter Aortic Valve Replacement.

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RGRaviteja GuddetiChrist HospitalJMJanelle MuuseUnited Hospital CenterSGSantiago GarciaChrist Hospital

Key Result

The simplified UNICORN technique for TAVR offers potential advantages over BASILICA, including enhanced leaflet tissue displacement and procedure simplification.

Key Points

  • This study aims to describe a simplified UNICORN technique for valve-in-valve and native TAVR patients at risk for coronary obstruction.
  • Described a simplified UNICORN procedure using radiofrequency energy and balloon inflations.
  • Compared this approach to the existing BASILICA technique in treating leaflet obstruction risks.
  • This simplified technique allows for creating a large fenestration effectively, decreasing obstruction risk.
  • Potential advantages include reduced need for complicated maneuvers like wire exchanges, improving procedural efficiency.

Structured PICO

P
Population
Patients undergoing valve-in-valve and native transcatheter aortic valve replacement (TAVR) at risk for coronary obstruction
I
Intervention
Simplified UNICORN (undermining iatrogenic coronary obstruction with radiofrequency needle) procedure

The simplified UNICORN technique represents a potentially advantageous leaflet modification strategy to prevent coronary obstruction during TAVR.

Limitations

  • Severely calcified leaflets that impede balloon advancement
  • Potential for leaflet fragment embolization with resultant coronary artery occlusion
  • Acute aortic insufficiency after balloon laceration

Abstract

OBJECTIVE: The UNICORN (undermining iatrogenic coronary obstruction with radiofrequency needle) technique represents an emerging leaflet modification strategy for patients undergoing transcatheter aortic valve replacement (TAVR) at risk for coronary obstruction. We describe a simplified UNICORN procedure in patients undergoing valve-in-valve and native TAVR. KEY STEPS: This approach employs radiofrequency energy to traverse the base of the prosthetic aortic leaflet, followed by serial balloon inflations to create a large fenestration and subsequent transcatheter heart valve deployment, removing the risk of leaflet obstruction. POTENTIAL PITFALLS: Technical challenges include severely calcified leaflets that impede balloon advancement, the potential for leaflet fragment embolization with resultant coronary artery occlusion, and acute aortic insufficiency after balloon laceration. TAKE-HOME MESSAGE: Compared with BASILICA (bioprosthetic aortic scallop intentional laceration to prevent iatrogenic coronary artery obstruction), UNICORN offers potential advantages, including enhanced leaflet tissue displacement and procedure simplification, minimizing the need for wire exchanges and snare retrieval maneuvers.

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Cite This Study

Guddeti et al. (2026) studied Patients undergoing transcatheter aortic valve replacement (TAVR) at risk for coronary obstruction. Simplified UNICORN technique vs. BASILICA was evaluated. The simplified UNICORN technique for TAVR offers potential advantages over BASILICA, including enhanced leaflet tissue displacement and procedure simplification.

synapsesocial.com/papers/6a06b9e2e7dec685947ac8f8https://doi.org/10.1016/j.jaccas.2026.108252
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