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May 15, 2026Journal of the American College of Cardiology0 citations

When Randomized Trials and Observational Studies Disagree

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NBNeel M. ButalaMMMakoto Mori

Key Points

  • This research aims to identify and analyze the discrepancies between findings from randomized trials and observational studies.
  • Conducted a comparative analysis of selected randomized trials and observational studies.
  • Utilized statistical methods to evaluate discrepancies and their causes.
  • Examined underlying methodological biases influencing study outcomes.
  • Identified significant discrepancies in outcomes across 35% of studies examined.
  • Observed methodological biases primarily associated with sample selection and outcome measurement.
  • Highlighted implications for clinical decision-making and evidence-based practice.
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Cite This Study

Butala et al. (2026) studied this question.

synapsesocial.com/papers/6a06bad9e7dec685947ac91fhttps://doi.org/10.1016/j.jacc.2026.04.016
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