In-line NIR coupled with machine learning to predict mechanical properties and dissolution profile of PLA-Aspirin

values of 97% and 96%, respectively in predicting the drug release at t = 96 h. This work for the first time reports the prediction of drug dissolution and mechanical properties of drug loaded polymer product from in-line data collected during the HME process. Supplementary Information: The online version contains supplementary material available at 10.1186/s42252-024-00063-5.