APM⁺ macrophages associated with plaque vulnerability via MIF–CD74 signaling: a multi-omics study

BACKGROUND: Atherosclerosis (AS) is a chronic vascular disease and the principal cause leading to ischemic cardiomyopathy (ICM). It involves complex metabolic dysregulation beyond the resolution of single-omics. Emerging evidence implicates arginine-proline metabolism (APM) in driving inflammation and impairing efferocytosis, yet the cellular basis of plaque instability remains elusive. METHODS: mouse. RESULTS: mouse. CONCLUSION: In summary, our study decodes the metabolic basis of inflammation shared between AS and ICM, suggesting an APMₕigh macrophage-centered regulatory axis across multiple omics layers. This work advances our understanding of the cardio-metabolic axis and suggests new avenues for targeted therapy.