Key result
Colder temperatures linked to more acute heart failure admissions, rising ~4% per degree in HFpEF.
Why the study?
Evidence on the association between ambient temperature and the onset of acute heart failure is scarce and mixed.
Does a decrease in ambient temperature increase the incidence of acute heart failure admissions across different ejection fraction phenotypes?
Observational
Does a decrease in ambient temperature increase the incidence of acute heart failure admissions across different ejection fraction phenotypes?
Lower ambient temperature is associated with a higher frequency of acute heart failure admissions, particularly in patients with HFpEF and HFmrEF, an effect potentially mediated by systolic blood pressure.
AIMS: Evidence on the association between ambient temperature and the onset of acute heart failure (AHF) is scarce and mixed. We sought to investigate the incidence of AHF admissions based on ambient temperature change, with particular interest in detecting the difference between AHF with preserved (HFpEF), mildly reduced (HFmrEF), and reduced ejection fraction (HFrEF). METHODS AND RESULTS: = 0.25 vs. 0.05, P < 0.001). In the sensitivity analysis, the decrease in the ambient temperature was associated with the greatest incremental increases in HFpEF, followed by HFmrEF and HFrEF patients (3.5% vs. 2.8% vs. 1.5% per -1°C, P < 0.001), with marked increase in admissions of hypertensive patients (systolic blood pressure >140 mmHg vs. 140-100 mmHg vs. <100 mmHg, 3.0% vs. 2.0% vs. 0.8% per -1°C, P for interaction <0.001). A mediator analysis indicated the presence of the mediator effect of systolic blood pressure. The in-hospital mortality rate (7.5%) did not significantly change according to ambient temperature (P = 0.62). CONCLUSIONS: Lower ambient temperature was associated with higher frequency of AHF admissions, and the effect was more pronounced in HFpEF and HFmrEF patients than in those with HFrEF.
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Jimba et al. (2022) conducted an observational in Acute heart failure. Ambient temperature decrease was evaluated on Incidence of acute heart failure admissions (p=<0.001). A decrease in ambient temperature was associated with increased acute heart failure admissions, with greater increases per -1°C in HFpEF (3.5%) and HFmrEF (2.8%) than HFrEF (1.5%) patients (P<0.001).
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