April 6, 2023Open Access

Azacitidine Is Synergistically Lethal with XPO1 Inhibitor Selinexor in Acute Myeloid Leukemia by Targeting XPO1/eIF4E/c-MYC Signaling

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Abstract

overexpression was associated with poor prognosis. In summary, KPT-330 with AZA exerted synergistic effects by suppressing XPO1/eIF4E/c-MYC signaling, which provided preclinical evidence for further clinical application of the novel combination in AML.

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Long et al. (Thu,) studied this question.

synapsesocial.com/papers/6a074df105e809827fd3dea3 https://doi.org/https://doi.org/10.3390/ijms24076816

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