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The of mono-protected amino acid (MPAA) ligands in accelerating cyclopalladation and palladium-catalyzed C–H was investigated using kinetic, spectroscopic, and methods. The catalytic relevance of characterized di-palladium was evaluated by kinetic analysis. The kinetic method of continuous (MCV) demonstrated that a complex containing a single MPAA-bridged-palladium core (Pd2 (MPAA) 1) is an active for the reactions studied. The experimental findings are with density functional theory calculations that indicate enantioinduction can be achieved by a single MPAA ligand bridging di-palladium catalyst through secondary sphere hydrogen-bonding that lower the barrier to C–H activation of the enantiomer.
Gair et al. (Thu,) studied this question.