Key result
Angiotensin 1-7 induces vasodilation and cardioprotection while opposing the pressor effects of Angiotensin II.
This review highlights the protective neuromodulatory and cardiovascular effects of Angiotensin-(1-7), particularly in the brain.
Angiotensin (Ang) (1-7) is the main component of the depressor and protective arm of the renin-angiotensin system. Ang-(1-7) induces vasodilation, natriuresis and diuresis, cardioprotection, inhibits angiogenesis and cell growth and opposes the pressor, proliferative, profibrotic, and prothrombotic actions mediated by Ang II. Centrally, Ang-(1-7) induces changes in mean arterial pressure and this effect may be linked with its inhibitory neuromodulatory action on norepinephrine neurotransmission. The present review is focused on the role of Ang-(1-7) as a protective agent in the brain.
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Mariela M. Gironacci (2015) conducted a review in Blood pressure and brain protection. Angiotensin-(1-7) was evaluated. Angiotensin-(1-7) acts as a protective agent in the brain, inducing vasodilation and cardioprotection while opposing the pressor and proliferative actions of Angiotensin II.
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