Key result
Extensive arterial vascular adaptations, including diameter decrease and enhanced flow-mediated dilation, occur within 3-8 weeks of inactivity in humans.
Why the study?
What are the magnitude and time course of arterial vascular adaptations to 3-8 weeks of inactivity in humans?
Observational
What are the magnitude and time course of arterial vascular adaptations to 3-8 weeks of inactivity in humans?
Inactivity for 3-8 weeks leads to significant arterial vascular adaptations, including decreased diameter and enhanced flow-mediated dilation, indicating that inactivity adaptations are not simply the inverse of exercise adaptations.
Inactivity may rapidly alter arterial function in immobilized patients; leaves open clinical relevance and reversibility.
We demonstrate that extensive arterial vascular adaptations occur within 3-8 wk of inactivity in humans. We put forth the hypothesis that the diameter decrease represents an adaptation to a lack of variation in peak shear stress. Furthermore, an enhanced flow-mediated dilation in deconditioned arteries implies that functional vascular adaptations to inactivity are not simply the inverse of adaptations to exercise.
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Groot et al. (2006) conducted an observational in Inactivity. Inactivity was evaluated on Arterial vascular adaptations (diameter decrease and flow-mediated dilation). Extensive arterial vascular adaptations, including diameter decrease and enhanced flow-mediated dilation, occur within 3-8 weeks of inactivity in humans.
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