Key result
Adjunctive posterior wall isolation reduces atrial tachyarrhythmia recurrence versus PVI alone in persistent AF.
Why the study?
PVI has limited effectiveness for persistent AF, and the clinical benefits of adjunctive posterior wall ablation remain uncertain.
Does pulmonary vein isolation with adjunctive posterior wall isolation reduce atrial tachyarrhythmia recurrence in patients with persistent atrial fibrillation?
Meta-Analysis
Does pulmonary vein isolation with adjunctive posterior wall isolation reduce atrial tachyarrhythmia recurrence in patients with persistent atrial fibrillation?
p-value: p=<.01
Adjunctive posterior wall isolation combined with pulmonary vein isolation reduces atrial tachyarrhythmia recurrence in patients with persistent atrial fibrillation without increasing adverse events.
Supports adjunctive PWI with PVI in persistent AF to reduce recurrence; confirms benefit in RCT meta-analysis.
Background: Pulmonary vein isolation (PVI) is the cornerstone of atrial fibrillation (AF) ablation. Its effectiveness for persistent atrial fibrillation (PeAF) is limited, and the benefits of adjunctive posterior wall ablation are uncertain. Objective: The purpose of this study was to perform a systematic review and meta-analysis of PVI with/without adjunctive PWI in patients with PeAF. Methods: We systematically searched PubMed, Embase, Cochrane, and ClinicalTrials.gov databases for randomized controlled trials (RCTs) comparing PVI with/without PWI in patients with PeAF. Random-effects model was used for the meta-analysis. Atrial tachyarrhythmia (ATA) was a composite of AF, atrial flutter, or atrial tachycardia. Results: <.01). Adverse events did not significantly differ between groups. Conclusion: Our findings support that adjunctive PWI to PVI is an effective strategy compared with PVI alone for reducing ATA recurrence in patients with PeAF without compromising safety. Notably, patients with long-standing PeAF may benefit more from PWI.
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Rivera et al. (2025) conducted a meta-analysis in Persistent atrial fibrillation (PeAF). Adjunctive posterior wall isolation (PWI) with pulmonary vein isolation (PVI) vs. Pulmonary vein isolation (PVI) alone was evaluated on Atrial tachyarrhythmia (ATA) recurrence (p=<.01). Adjunctive posterior wall isolation to pulmonary vein isolation reduced atrial tachyarrhythmia recurrence compared with PVI alone in patients with persistent atrial fibrillation (P<.01).
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