Identification of HIV transmitting CD11c+ human epidermal dendritic cells

Q: What does this research mean for the field?

CD11c+ human epidermal dendritic cells in anogenital tissues play a key role in the sexual transmission of HIV. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Kirstie M. Bertram; Rachel A. Botting; Heeva Baharlou; Jake W. Rhodes; Hafsa Rana; J. Dinny Graham; Ellis Patrick; James Fletcher; T. Plasto; Naomi R. Truong; Caroline Royle; Chloe M. Doyle; Orion Tong; Najla Nasr; Laith Barnouti; Mark P. Kohout; Andrew J. Brooks; Michael Wines; Peter Haertsch; Jake Lim; M. Gosselink; Grahame Ctercteko; Jacob D. Estes; Melissa J. Churchill; Paul Cameron; Eric Hunter; Muzlifah Haniffa; Anthony L. Cunningham; Andrew N. Harman

doi:10.1038/s41467-019-10697-w

Ask about this paper

Answers are grounded in this paper and cite their sources.

Abstract

cell population, which is transcriptionally similar to LCs but does not appear to function as antigen-presenting cells or acts as HIV target cells. Our findings reveal that epidermal DCs in anogenital tissues potentially play a key role in sexual transmission of HIV.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Bertram et al. (2019) studied this question.

synapsesocial.com/papers/6a07a94f4125062f2c4ab72b https://doi.org/10.1038/s41467-019-10697-w

View Full Paper

Ask AI

Bookmark

Share

Identification of HIV transmitting CD11c+ human epidermal dendritic cells

Ask about this paper

Abstract

Discussion

Cite This Study

Identification of HIV transmitting CD11c+ human epidermal dendritic cells

Ask about this paper

Abstract

Discussion

Cite This Study

Keep reading

Keep reading