Key result
Renal insufficiency, defined as an estimated GFR <70 ml/min, was independently associated with an increased risk of cardiovascular disease-related death (HR 1.68; 95% CI 1.33-2.13).
Why the study?
Does renal insufficiency increase the risk of cardiovascular disease-related and all-cause mortality in the general population?
Cohort (n=8,786)
Yes
Does renal insufficiency increase the risk of cardiovascular disease-related and all-cause mortality in the general population?
Effect estimate: HR 1.68 (95% CI 1.33-2.13)
Absolute Event Rate: 20.5% vs 4.1%
Renal insufficiency, indicated by reduced GFR or proteinuria, is an independent risk factor for cardiovascular and all-cause mortality in the general US population.
No takes yet. Share an insight, caveat, or question.
Renal insufficiency may flag higher CVD mortality risk for monitoring; extends associations to a representative US cohort but leaves causality and interventions open.
Muntner et al. (2002) conducted a cohort in General population (n=8,786). Renal insufficiency (estimated GFR <70 ml/min) vs. Estimated GFR ≥90 ml/min was evaluated on Cardiovascular disease-related mortality (HR 1.68, 95% CI 1.33-2.13). Renal insufficiency, defined as an estimated GFR <70 ml/min, was independently associated with an increased risk of cardiovascular disease-related death (HR 1.68; 95% CI 1.33-2.13).
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