March 1, 2002Journal of the American Society of Nephrology
Renal Insufficiency and Subsequent Death Resulting from Cardiovascular Disease in the United States
Key result
Renal insufficiency, defined as an estimated GFR <70 ml/min, was independently associated with an increased risk of cardiovascular disease-related death (HR 1.68; 95% CI 1.33-2.13).
Why the study?
Does renal insufficiency increase the risk of cardiovascular disease-related and all-cause mortality in the general population?
Population
Participants 30 to 74 years of age at baseline from the Second National Health and Nutrition Examination…
Comparison
Renal insufficiency vs Normal renal function
Design
Cohort
Follow-up
16 years
Authors
Discussion
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Implication
Renal insufficiency may flag higher CVD mortality risk for monitoring; extends associations to a representative US cohort but leaves causality and interventions open.
Study Design
Type
Cohort (n=8,786)
Multicenter
Yes
Structured PICO
Does renal insufficiency increase the risk of cardiovascular disease-related and all-cause mortality in the general population?
P
Population
Participants 30 to 74 years of age at baseline (1976-1980) from the Second National Health and Nutrition Examination Survey Mortality Study, with urinary protein dipstick measurements (n = 8786) or serum creatinine levels of <=3.0 mg/dl (n = 6354).
I
Intervention
Renal insufficiency (defined by urinary protein levels 30 to 299 or >=300 mg/dl, or estimated GFR <70 ml/min)
C
Comparator
Normal renal function (urinary protein <30 mg/dl or estimated GFR >=90 ml/min)
O
Outcome
Cardiovascular disease-related mortality and all-cause mortalityhard clinical
Main Result
Effect estimate: HR 1.68 (95% CI 1.33-2.13)
Absolute Event Rate: 20.5% vs 4.1%
Renal insufficiency, indicated by reduced GFR or proteinuria, is an independent risk factor for cardiovascular and all-cause mortality in the general US population.
Cite This Study
Muntner et al. (2002) conducted a cohort in General population (n=8,786). Renal insufficiency (estimated GFR <70 ml/min) vs. Estimated GFR ≥90 ml/min was evaluated on Cardiovascular disease-related mortality (HR 1.68, 95% CI 1.33-2.13). Renal insufficiency, defined as an estimated GFR <70 ml/min, was independently associated with an increased risk of cardiovascular disease-related death (HR 1.68; 95% CI 1.33-2.13).