Key result
Submillimeter 3D diffusion tensor MRI reveals heterogeneous transmural fiber angle distribution across human atrial regions.
Submillimeter diffusion tensor MRI provides detailed, non-destructive mapping of human atrial myofiber architecture and its intersubject variability, which may enhance understanding of atrial rhythm disorders.
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May inform atrial arrhythmia models; leaves open in vivo validation before clinical translation.
Pashakhanloo et al. (2016) studied Atrial anatomy (n=8). 3-dimensional diffusion tensor magnetic resonance imaging was evaluated on Fibrous organization and transmural fiber angle distribution of the human atria. Submillimeter 3D diffusion tensor MRI of 8 ex vivo human heart specimens mapped atrial fibrous organization, revealing heterogeneous transmural fiber angle distribution across different regions.
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