Key result
Cardiac sodium channel dysfunction is linked to ventricular dysfunction and DCM, offering precision therapy targets.
Why the study?
Debate persists regarding whether left ventricular remodeling is a bona fide feature of cardiac sodium channel dysfunction or secondary to tachyarrhythmias or conduction disturbances, prompting a critical digest of available literature.
This review appraises the pathophysiological link between cardiac sodium channel dysfunction and dilated cardiomyopathy, highlighting mechanisms and implications for precision therapy.
May inform SCN5A evaluation in DCM; leaves open prospective validation of precision therapies.
) produce a remarkably diverse set of electrical and structural phenotypes, one of them being dilated cardiomyopathy. There has been debate about whether left ventricular remodeling is a bona fide phenotypic feature of cardiac sodium channel dysfunction, or a consequence of tachyarrhythmias or conduction disturbances. In light of recent findings, a critical digest of the available experimental and medical literature is necessary. This paper provides a critical appraisal of the evidence linking a dysfunctional cardiac sodium channel to ventricular dysfunction, and discusses the potential mechanisms involved in shaping this phenotype along with implications for precision therapy.
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Babken Asatryan (2019) conducted a review in Cardiac Sodium Channel Dysfunction and Dilated Cardiomyopathy. Cardiac sodium channel dysfunction is linked to ventricular dysfunction and dilated cardiomyopathy, with emerging mechanisms offering implications for precision therapy.
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