Key result
Nonmuscle myosin II plays crucial roles in generating cell polarity, cell migration, and cell-cell adhesion, functioning as a contractile element and potentially as a scaffold molecule.
Population
Mammalian systems (transgenic mice, siRNAs), Drosophila, and Aplysia model systems
Design
Review
Authors
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Informs CV cell dynamics research; leaves open clinical translation of NMII targeting.
This review highlights the emerging roles of nonmuscle myosin II in cell polarity, migration, and adhesion, acting as both a mechanical and scaffolding protein.
Conti et al. (2007) conducted a review in Cellular processes (cell polarity, migration, adhesion). Nonmuscle myosin II (NMII) was evaluated. Nonmuscle myosin II plays crucial roles in generating cell polarity, cell migration, and cell-cell adhesion, functioning as a contractile element and potentially as a scaffold molecule.
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