Key result
Atherosclerosis markers cIMT, CACS, and PWV are linked to mortality and major events across CKD stages.
Why the study?
Non-invasive cardiovascular disease risk prediction in subclinical stages to stratify patients and tailor interventions remains an unmet need in chronic kidney disease.
Are non-invasive measures of subclinical atherosclerosis and arterial stiffness (cIMT, CACS, PWV) associated with all-cause mortality, CV mortality, and CV events in patients with chronic kidney disease?
Meta-Analysis
Are non-invasive measures of subclinical atherosclerosis and arterial stiffness (cIMT, CACS, PWV) associated with all-cause mortality, CV mortality, and CV events in patients with chronic kidney disease?
Non-invasive measures of atherosclerosis and arterial stiffness (cIMT, CACS, PWV) are associated with increased risk of mortality and cardiovascular events in patients across all stages of chronic kidney disease.
May enhance CKD risk stratification; confirms associations across stages but leaves open whether targeting these markers improves outcomes.
BACKGROUND: Non-invasive cardiovascular disease (CVD) risk prediction, in subclinical stages, aiming to stratify patients and tailor interventions remains an unmet need in chronic kidney disease (CKD). In this meta-analysis, we summarize the association of carotid intima-media thickness (cIMT), coronary artery calcium score (CACS) and pulse wave velocity (PWV) with all-cause mortality, cardiovascular (CV) mortality and CV events in non-dialysis CKD and patients on haemodialysis. METHODS: Systematic review and meta-analysis of prospective cohort studies. RESULTS: : 62.6%). CONCLUSIONS: Non-invasive measures of atherosclerosis and arterial stiffening are associated with all-cause and CV mortality as well as CV events among patients with all stages of CKD. These markers could be considered for the evaluation of CV morbidity and mortality risks. Moreover, the results of this meta-analysis support the study of interventions, with effect on these markers of vascular disease, on long-term CVD outcomes.
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Κouis et al. (2019) conducted a meta-analysis in Chronic kidney disease (CKD). Non-invasive measures of atherosclerosis and arterial stiffness (cIMT, CACS, PWV) was evaluated on All-cause mortality, cardiovascular mortality, and cardiovascular events. Non-invasive measures of atherosclerosis and arterial stiffening (cIMT, CACS, PWV) are associated with all-cause and cardiovascular mortality and events in patients with all stages of CKD.
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