Key result
The use of embolic protection devices during transcatheter aortic valve implantation is associated with a lower 30-day stroke rate and smaller volume of ischemic lesions, but not reduced mortality.
Why the study?
Does the use of embolic protection devices reduce mortality, stroke, and ischemic cerebral lesions in patients undergoing transcatheter aortic valve implantation?
Meta-Analysis
Does the use of embolic protection devices reduce mortality, stroke, and ischemic cerebral lesions in patients undergoing transcatheter aortic valve implantation?
Embolic protection devices during TAVI do not significantly reduce mortality or the incidence of new ischemic lesions, but they may reduce the total volume of ischemic lesions.
BACKGROUND: The use of embolic protection devices (EPD) may theoretically reduce the occurrence of cerebral embolic lesions during transcatheter aortic valve implantation. Available evidence from single studies is inconclusive. The aim of the present meta-analysis was to assess the safety and efficacy profile of current EPD. METHODS AND CONCLUSIONS: The use of EPD is not associated with a reduced rate of mortality and new ischemic cerebral lesions. The use of EPD during transcatheter aortic valve implantation seems to be associated with a lower 30-day stroke rate, although this result is driven by a single nonrandomized study. The use of EPD is associated with a smaller volume of ischemic lesions, and smaller total volume of ischemic lesions.
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Testa et al. (2018) conducted a meta-analysis in Transcatheter aortic valve implantation. Embolic protection devices (EPD) was evaluated on Mortality and new ischemic cerebral lesions (p==0.02). The use of embolic protection devices during transcatheter aortic valve implantation is associated with a lower 30-day stroke rate and smaller volume of ischemic lesions, but not reduced mortality.
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