Key result
Higher uric acid/albumin ratio linked to ~36% greater risk of late AF recurrence after ablation.
Why the study?
AF recurrences remain a major problem after successful catheter ablation, and the predictive value of the uric acid/albumin ratio for post-ablation recurrence had not been established.
Does the uric acid/albumin ratio predict late recurrence of atrial fibrillation in patients who underwent successful cryoballoon catheter ablation?
Observational (n=170)
Does the uric acid/albumin ratio predict late recurrence of atrial fibrillation in patients who underwent successful cryoballoon catheter ablation?
The uric acid/albumin ratio is a simple, inexpensive biomarker that independently predicts late recurrence of atrial fibrillation following successful cryoballoon catheter ablation.
May stratify post-ablation recurrence risk; hypothesis-generating and requires prospective validation before clinical use.
Objective: Despite improvements in the technology of catheter ablation of atrial fibrillation (AF), recurrences are still a major problem, even after a successful procedure. The uric acid/albumin ratio (UAR), which is an inexpensive and simple laboratory parameter, has recently been introduced in the literature as a predictor of adverse cardiovascular events. Hence, we aimed to investigate the relationship between the UAR and AF recurrence after catheter ablation. Methods: A total of 170 patients who underwent successful catheter ablation for AF were included. The primary outcome was the late recurrence after treatment. The recurrence (+) and recurrence (−) groups were compared for clinical, laboratory and procedural characteristics as well as the predictors of recurrence assessed by regression analysis. Results: In our study population, 53 (26%) patients developed AF recurrence after catheter ablation. Mean UAR was higher in the recurrence (+) group compared to recurrence (−) group (2.4 ± 0.9 vs. 1.8 ± 0.7, p < 0.01). In multivariable regression analysis, left atrial diameter (HR: 1.08, 95% CI: 1.01−1.16, p = 0.01) and UAR (HR:1.36, 95% CI: 1.06−1.75, p = 0.01) were found to be independent predictors of recurrence. In ROC analysis, the UAR > 1.67 predicted recurrence with a sensitivity of 77% and a specificity of 57% (AUC 0.68, p < 0.01). Conclusion: For the first time in the literature, the UAR were found to be correlated independently with AF recurrence after catheter ablation.
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Karataş et al. (2022) conducted an observational in Atrial Fibrillation (n=170). Uric acid/albumin ratio (UAR) was evaluated on Late recurrence of atrial fibrillation after treatment (HR 1.36, 95% CI 1.06-1.75, p=0.01). A higher uric acid/albumin ratio was independently associated with an increased risk of late atrial fibrillation recurrence after successful catheter ablation (HR 1.36; 95% CI 1.06-1.75; p=0.01).
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