This review discusses experimental and simulation data on how gain-of-function potassium channel mutations contribute to arrhythmia susceptibility in short QT syndrome.
No change to short QT syndrome management; leaves open mutation-specific therapeutic targets.
and of the links between these changes and arrhythmia susceptibility. Data from experimental and simulation studies and future directions for research in this field are considered. This article is part of the theme issue 'The heartbeat: its molecular basis and physiological mechanisms'.
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Hancox et al. (2023) studied this question.
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