Key result
Dobutamine infusion decreased arterial baroreflex sensitivity from 12+/-2 to 3+/-1 ms/mm Hg (P<0.01), impairing baroreflex control of the sinus node during exercise stress testing.
Why the study?
Does dobutamine infusion alter arterial baroreflex control of the sinus node in healthy subjects?
Population
13 healthy subjects
Comparison
Dobutamine infusion vs Placebo
Design
Other
Authors
Loading...
Dobutamine impairs baroreflex sensitivity in simulated exercise; extends evidence that central command is required for baroreflex resetting beyond hemodynamics alone.
RCT (n=13)
Does dobutamine infusion alter arterial baroreflex control of the sinus node in healthy subjects?
Absolute Event Rate: 3% vs 12%
p-value: p=<0.01
Dobutamine infusion impairs baroreflex control of the sinus node, indicating that baroreflex control is not reset when hemodynamic characteristics of exercise are reproduced without central command and muscle afferent changes.
Borne et al. (1999) conducted an RCT in Healthy subjects (n=13). Dobutamine infusion vs. Placebo was evaluated on Arterial baroreflex sensitivity (p=<0.01). Dobutamine infusion decreased arterial baroreflex sensitivity from 12+/-2 to 3+/-1 ms/mm Hg (P<0.01), impairing baroreflex control of the sinus node during exercise stress testing.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: