Key result
Levosimendan had neutral effects on myocardial oxygen consumption and cardiac efficiency in healthy male volunteers, whereas dobutamine increased oxygen requirement.
Why the study?
Does levosimendan improve cardiac efficiency and myocardial oxygen consumption compared to dobutamine and sodium nitroprusside in healthy male volunteers?
Population
Healthy male volunteers
Comparison
Levosimendan vs Dobutamine and sodium nitroprusside
Authors
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Supports testing in heart failure patients for energetic benefits; leaves open translation from healthy volunteers.
Does levosimendan improve cardiac efficiency and myocardial oxygen consumption compared to dobutamine and sodium nitroprusside in healthy male volunteers?
Levosimendan provides balanced inotropism and vasodilatation without increasing myocardial oxygen consumption in healthy volunteers, suggesting energetic advantages over dobutamine.
Ukkonen et al. (1997) studied Healthy volunteers. Levosimendan vs. Dobutamine and sodium nitroprusside was evaluated on k(mono) (index of oxygen consumption) and cardiac efficiency. Levosimendan had neutral effects on myocardial oxygen consumption and cardiac efficiency in healthy male volunteers, whereas dobutamine increased oxygen requirement.
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