Key result
Higher physical activity is linked to increased LA diameter in males and LV mass in females.
Why the study?
Current knowledge about physical activity and cardiac remodeling stems mainly from cross-sectional studies of athletes, leaving a knowledge gap regarding this longitudinal association in the general adult and elderly population.
Does higher cumulative physical activity affect left atrial and ventricular structure and function in a general adult and elderly population?
Observational (n=594)
Does higher cumulative physical activity affect left atrial and ventricular structure and function in a general adult and elderly population?
p-value: p=0.037
Higher cumulative physical activity in the general population is associated with physiological cardiac chamber enlargement without deterioration of pump function.
These associations should not change activity guidance; leaves open whether remodeling is adaptive or prognostic in general adults.
Background: Current knowledge about the relationship between physical activity (PA) and cardiac remodeling is mainly derived from cross-sectional studies of athletes, and there is a knowledge gap of this association in the general adult and elderly population. Therefore, we aimed to explore the longitudinal association between cumulative PA and change in cardiac structure and function in a general adult and elderly population. Methods: This longitudinal study includes 594 participants from the sixth (Tromsø6, 2007-08) and seventh (Tromsø7, 2015-16) survey of the Tromsø Study. Cardiac structure and function were assessed by echocardiography at two time points, and PA was self-reported by questionnaire at both time points. PA volume was expressed as cumulative PA (Low, Moderate, and Hard) and the association with left atrial (LA) and left ventricular (LV) structure and function was assessed using ANCOVA. Results: = 0.037). When stratified by sex or age, these changes in LVMi and indexed LV diameter (LVDi) were only significant in females. No significant associations were observed between cumulative PA and change in relative wall thickness, E/e' ratio, e' velocity, LV ejection fraction, and LADi/LVDi ratio. Conclusion: Higher levels of cumulative PA were associated with increased LADi in males and participants <65 years, and with increased LVMi and LVDi in females. Despite cardiac chamber enlargement, the pump function of the heart did not change with higher levels of PA, and the atrioventricular ratio was unchanged. Our results indicate that cardiac chamber enlargement is a physiological response to PA.
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Heitmann et al. (2022) conducted an observational in General adult and elderly population (n=594). Cumulative physical activity vs. Lower levels of physical activity was evaluated on Change in left atrial and left ventricular structure and function (p=0.037). Higher cumulative physical activity was associated with increased left atrial diameter in males and those <65 years, and increased left ventricular mass and diameter in females.
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