Key result
OSDES verifies sex among healthy undergraduates with an AUC of ~0.94.
Why the study?
Does the Ogunlade Sex Determination Electrocardiographic Score (OSDES) accurately verify sex in apparently healthy fresh undergraduates?
Cross-Sectional (n=2,442)
Blinded evaluators
No
Does the Ogunlade Sex Determination Electrocardiographic Score (OSDES) accurately verify sex in apparently healthy fresh undergraduates?
Effect estimate: AUC 0.943
The Ogunlade Sex Determination Electrocardiographic Score (OSDES) demonstrates high sensitivity, specificity, and accuracy for sex verification using resting 12-lead ECGs in young Nigerian adults.
May support ECG-based sex verification in young Nigerian adults; leaves open validation in broader clinical populations.
Background: Sex verification using electrocardiogram (ECG) is a new application of the biological signal.Objective: This study aimed to determine the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of an electrocardiographic score in sex verification.Methods: A total of 2442 apparently healthy fresh undergraduates who presented for health screening in a tertiary institution were recruited for the study. The technical team documented the sex of the participants and had their resting 12-lead ECG recorded according to standard protocol. Two physicians who were blinded to the participants and the recorded sex utilized Ogunlade Sex Determination Electrocardiographic Score (OSDES) to determine the sex. The validity of OSDES was estimated using sex recorded by the technical team as the standard while the accuracy of scoring system was determined using receiver operating characteristic curve.Results: The mean (± standard deviation) of age of the participants was 20.71 ± 3.62 years. Among the male population, true positives (TPs), false positives (FPs), false negatives (FNs), and true negatives (TN) were 1131, 49, 90, and 1172, respectively. Among the females TP, FP, FN, and TN were 1172, 90, 49, and 1131, respectively. Among males, the sensitivity, specificity, PPV, and NPV were 92.63% (95% confidence interval [CI]: 91.02-94.03%), 95.99% (95% CI: 94.73-97.02%), 95.85% (95% CI: 94.55-96.91%), and 92.87% (CI: 91.31-94.23%) respectively while among the females, the sensitivity, specificity, PPV, and NPV were 95.99% (95% CI: 94.73-97.02%), 92.63% (95% CI: 91.02-94.03%), 92.87% (95% CI: 91.31-94.23%), and 95.85% (95% CI: 91.02-94.03%) respectively. The area under curve was 0.943.Conclusion: This study concluded that ECG has a reasonable level of sensitivity and specificity with excellent accuracy in verification of sex among fresh Nigerian undergraduates.
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Asafa et al. (2016) conducted a cross-sectional in Healthy (n=2,442). Ogunlade Sex Determination Electrocardiographic Score (OSDES) vs. Sex recorded by technical team was evaluated on Accuracy of OSDES in sex verification (AUC 0.943). The Ogunlade Sex Determination Electrocardiographic Score accurately verified sex among healthy undergraduates, achieving an area under the curve of 0.943.
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