Interindividual Variation in Cardiorespiratory Fitness: A Candidate Gene Study in Han Chinese People

Figures

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  Figure 1. Distribution of peak oxygen uptake (VO2peak) data in the study participants.

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  Figure 2. Variance in peak oxygen uptake in the study participants explained by genetic variants alone (a) and by genetic variants plus anthropometric covariates (b). Abbreviations for gene names: ACE, angiotensin-converting enzyme; AGTR1, angiotensin II receptor type 1; BDKRB2, bradykinin receptor B2; GDF8, growth differentiation factor 8 (also known as ‘myostatin’).

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  Figure 3. Box-and-whisker plots showing peak oxygen uptake (VO2peak) in the study participants according to genetic variations in the genes for angiotensin-converting enzyme (ACE; rs4295), angiotensin II receptor type 1 (AGTR1; rs275652), and growth differentiation factor 8 (GDF8, also known as ‘myostatin’; rs7570532). The lines in the box represent the first, second (median) and third quartiles, and the whiskers represent 1.5 × interquartile ranges. Each dot represents one individual within the specified genotype. (*) Depicts a statistically significant difference from CC genotype in ACE rs4295 polymorphism at p < 0.05. (†) Depicts a statistically significant difference from CC genotype in AGTR1 rs275652 polymorphism at p < 0.05.

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  Figure 4. Peak oxygen uptake (VO2peak) levels in the study participants according to the genotype score (computed by using a weighted score of angiotensin-converting enzyme rs4295, angiotensin II receptor type 1 rs275652 and growth differentiation factor 8 rs7570532 genotypes). Abbreviations/symbols: a.u., arbitrary units; a, difference from 0–0.9 a.u. at p<0.05; b, difference from 1.0–1.9 a.u. at p < 0.05; c, difference from 2.0–2.9 a.u. at p < 0.05; d, difference from 3.0–3.9 a.u. at p < 0.05.