HiDRA: Hierarchical Network for Drug Response Prediction with Attention

value of 0.8647. We also confirmed that the model gives high attention to drug-target genes and cancer-related pathways when predicting a response. The validity of predicted results was proven by in vitro cytotoxicity assay. Overall, we propose that our hierarchical and interpretable AI-based model is capable of interpreting intrinsic characteristics of cancer cells and drugs for accurate prediction of cancer-drug responses.