Key result
Increased mean platelet volume on admission was independently associated with a decreased incidence of pre-PCI patent infarct-related artery (P=0.004) and post-PCI normal TIMI flow (P<0.001).
Why the study?
Is mean platelet volume on admission associated with pre- and post-PCI TIMI flow in patients with STEMI undergoing primary PCI?
Observational (n=840)
Is mean platelet volume on admission associated with pre- and post-PCI TIMI flow in patients with STEMI undergoing primary PCI?
Answers are grounded in this paper and cite their sources.
Higher mean platelet volume on admission is associated with worse pre- and post-PCI TIMI flow in patients with STEMI.
Platelets play a role in the pathogenesis of ST-segment elevation myocardial infarction (STEMI). We assessed the relationship between mean platelet volume (MPV) on admission and pre- and postinterventional flow with the infarct-related artery (IRA) in patients with STEMI. We prospectively included 840 patients with STEMI who underwent primary percutaneous coronary intervention (PCI). The patients were divided into 3 groups according to MPV tertiles. Pre- and post-PCI Thrombolysis In Myocardial Infarction (TIMI) flow grade was determined. Initial TIMI flow grade 3 was accepted as patent IRA. After the primary PCI, normal flow was defined as post-PCI TIMI flow 3. When the MPV was increased, the incidence of pre-PCI patent IRA (P = .004) and post-PCI normal TIMI flow (P < .001) was significantly decreased. Multivariate analysis showed that MPV was independently associated with post-PCI TIMI flow grade.
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Elbasan et al. (2012) conducted an observational in ST-Segment Elevation Myocardial Infarction (STEMI) (n=840). Mean platelet volume (MPV) vs. Lower MPV tertiles was evaluated on Pre-PCI patent infarct-related artery and post-PCI normal TIMI flow (p=<0.001). Increased mean platelet volume on admission was independently associated with a decreased incidence of pre-PCI patent infarct-related artery (P=0.004) and post-PCI normal TIMI flow (P<0.001).
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