An increased platelet-to-lymphocyte ratio was independently associated with long-term cardiovascular mortality after acute coronary syndrome (HR 1.07 per 1 SD increase), an effect observed exclusively in patients aged 65 years or older.
Cohort (n=681)
No
Does an elevated platelet-to-lymphocyte ratio predict long-term cardiovascular mortality in patients with acute coronary syndrome?
The platelet-to-lymphocyte ratio is a strong, independent predictor of long-term cardiovascular mortality in ACS patients, but this prognostic value is exclusively observed in patients aged 65 years and older.
Effect estimate: HR 1.07 (95% CI 1.03-1.10)
p-value: p=<0.001
Aims: Personalized risk stratification within the ageing society after acute coronary syndrome (ACS) remains scarce but in urgent need. Increased platelet activity together with inflammatory activation play a key role during ACS. We aimed to evaluate the age-specific prognostic potential of the platelet to lymphocyte ratio (PLR) on long-term cardiovascular mortality after ACS. Methods and results: = 0.901]. Conclusion: The present investigation highlights a strong and independent age-specific association of the PLR with cardiovascular mortality in patients with ACS. The PLR only allows to identify patients ≥65 years at high risk for fatal events after ACS-even from a long-term perspective.
Kazem et al. (Wed,) conducted a cohort in Acute coronary syndrome (n=681). Platelet-to-lymphocyte ratio (PLR) was evaluated on Cardiovascular mortality (HR 1.07, 95% CI 1.03-1.10, p=<0.001). An increased platelet-to-lymphocyte ratio was independently associated with long-term cardiovascular mortality after acute coronary syndrome (HR 1.07 per 1 SD increase), an effect observed exclusively in patients aged 65 years or older.
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