Key result
Higher scalp hair iron strongly correlates with lower systemic inflammatory index in CAD patients.
Why the study?
The relationship between trace element concentration and morbidity is under investigation to better understand pathological processes in coronary artery atherosclerosis development and progression.
Observational (n=35)
No
Answers are grounded in this paper and cite their sources.
Scalp hair concentrations of trace elements like iron, lithium, antimony, and chromium correlate significantly with systemic inflammatory indices in patients with epicardial coronary artery disease, suggesting a potential link between trace metal homeostasis and atherosclerotic inflammation.
Background: Coronary artery atherosclerosis development and progression are related to generic, clinical, and lifestyle factors combined with inflammatory activation. The relationship between trace element concentration and morbidity is under investigation to gain a clearer understanding of underlying pathological processes. Methods: Thirty-five consecutive patients (22 males and 13 females) with a median [interquartile range (IQR)] age of 67 (61-73) years presenting with anginal symptoms were included in the single center prospective analysis in 2022 and divided into a epicardial coronary artery disease (CAD) and non-CAD group. Scalp hair chemical analysis and inflammatory markers from a peripheral blood count were analyzed. Similar correlations were not found in non-CAD group. Conclusions: The correlation between scalp hair lithium (Li), antimony (Sb), chromium (Cr) and iron (Fe) concentration and the systemic inflammatory index (SII) were revealed only in patients with coronary artery disease. Our analysis identified a strong correlation between inflammatory activation and iron concentration.
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Urbanowicz et al. (2023) conducted an observational in Epicardial Coronary Artery Disease (n=35). Hair trace elements (Lithium, Antimony, Chromium, Iron) vs. Non-CAD patients was evaluated on Correlation between hair iron (Fe) concentration and systemic inflammatory index (SII) in CAD patients (r = -0.604, p=0.008). Scalp hair iron concentration strongly and inversely correlated with the systemic inflammatory index (r = -0.604) in patients with epicardial coronary artery disease.
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