Key result
Phosphorylation of porcine cardiac and rabbit skeletal myosins had no significant effect on their calcium binding properties, with both binding approximately 2 mol of Ca2+/mol of myosin.
Phosphorylation of cardiac and skeletal myosins does not significantly alter their calcium binding properties.
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No effect on animal myosin Ca2+ binding cautions against assuming regulatory role clinically; leaves open relevance to human contractility.
Holroyde et al. (1979) studied this question. Phosphorylation vs. Unphosphorylated myosin was evaluated on Ca2+ binding properties. Phosphorylation of porcine cardiac and rabbit skeletal myosins had no significant effect on their calcium binding properties, with both binding approximately 2 mol of Ca2+/mol of myosin.
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