Key result
In patients under 40 with inflammatory myopericardial syndrome, the Fibrosis-4 index was significantly higher in those with late gadolinium enhancement, but 1-year major cardiovascular events did not differ significantly between LGE-positive and LGE-negative groups (2.6% vs 2.8%, p=0.665).
Why the study?
The study aimed to explore the relationship between the Fibrosis-4 index and major adverse cardiovascular events within one year in cases of inflammatory myopericardial syndrome.
Does the Fibrosis-4 index or presence of LGE predict major adverse cardiovascular events in patients under 40 years of age with acute myocarditis?
Cross-Sectional (n=152)
No
Does the Fibrosis-4 index or presence of LGE predict major adverse cardiovascular events in patients under 40 years of age with acute myocarditis?
In patients under 40 with acute myocarditis, Fib-4i is associated with the presence of LGE on CMR but does not predict major adverse cardiovascular events at 1 year.
Introduction:Fibrosis-4 index (Fib-4i) is a useful and practical indicator of fibrosis risk in chronic liver disease.The study aimed to explore the relationship between Fib-4i and major adverse cardiovascular events (MACEs) within one year in cases of inflammatory myopericardial syndrome (IMPS).Methods: Between January 2018 and December 2023, 152 patients diagnosed with IMPS were stratified into two groups based on the presence of late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging.The Fib-4i was calculated at admission, and MACEs due to IMPS were recorded at 12 months.Results: Group 1 consisted of 36 LGE-negative patients, while group 2 consisted of 116 LGE-positive patients.The Fib-4i was higher in group 2 than in group 1 (p=0.014).Furthermore, it was found that aspartate aminotransferase, high-sensitivity (hs) troponin T, N-terminal pro-brain natriuretic peptide, and C-reactive protein (CRP) were higher in group 2 than in group 1 (respectively, p=0.03, p=0.002, p=0.008, p=0.014).No difference in MACEs between groups was observed at one month, six months, and one year (p=0.581, p=0.558, p=0.665, respectively).However, a positive correlation was observed between the Fib-4i and both hs-troponin T and CRP.Conclusion: Fib-4i was higher in patients with LGE than in those without LGE.However, its predictive power for MACEs could not be demonstrated.
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Altuntaş et al. (2026) conducted a cross-sectional in Inflammatory myopericardial syndrome (IMPS) / Acute myocarditis (n=152). Late gadolinium enhancement (LGE) positive on CMRI vs. LGE negative on CMRI was evaluated on Major cardiovascular events (MACE) at 1 year (p=0.665). In patients under 40 with inflammatory myopericardial syndrome, the Fibrosis-4 index was significantly higher in those with late gadolinium enhancement, but 1-year major cardiovascular events did not differ significantly between LGE-positive and LGE-negative groups (2.6% vs 2.8%, p=0.665).
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