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May 13, 2026Journal of the American Chemical Society

Sinefungin Biosynthesis Employs a B ₁₂ -Dependent Radical S -Adenosyl- l -methionine Enzyme Catalyzing C-Adenosylation of Arginine

Koki Ueno Richiro Ushimaru Yi Yang Kazuki Shimada Ikuro Abe

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Key Points

The aim is to explore the biosynthesis of sinefungin and identify the enzymatic processes involved.
Investigation of the radical SAM enzyme family
Characterization of the enzyme's activity
Analysis of the assembly pathway for conjugates
Identification of a novel B12-dependent radical SAM enzyme
Revealed unique mechanisms for C-adenosylation of arginine
Demonstrated unconventional pathways for amino acid-nucleoside conjugate synthesis

Implication

Demonstrates an unconventional biosynthesis pathway for amino acid-nucleoside conjugates in nature, highlighting a novel enzyme.

Abstract

-dependent radical SAM enzyme family and unveils an unconventional assembly pathway for amino acid-nucleoside conjugates in nature.

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Cite This Study

Ueno et al. (2026) studied this question.

synapsesocial.com/papers/6a0808ffa487c87a6a40b173 https://doi.org/10.1021/jacs.6c05246

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