Efficient cell-by-cell simulation of DNA double strand breaks, chromosome aberrations, and cell survival for low- and high-LET radiation particles using TOPAS-nBio and MEDRAS
Novel method accelerates DNA damage simulation in single cells, suggesting improved radiation therapy predictions.
Key Points
This research aims to develop a more efficient method for simulating DNA double strand breaks, chromosome aberrations, and cell survival during radiation exposure.
Introduced a pre-calculated single-particle-track standard DNA damage data library using TOPAS-nBio.
Simulated DNA damage outcomes using MEDRAS-MC on a cell-by-cell basis with various radiation types.
Examined the method through comparisons with three in vitro experiments involving different radiation particles.
Simulations accurately predicted chromosome aberrations and cell lethality for X-rays, protons, and alpha particles.
Data library significantly reduced computation time for assembling DNA damage data at varying dose levels.
Observed discrepancies between in silico predictions and experimental data were discussed, highlighting areas for further research.