Multifunctional Nanozyme Hydrogel for Oxidative Stress Scavenging and Mitophagy Activation in Spinal Cord Injury Repair

, Que@MCEu/H markedly reduces lesion cavities and fibrotic scarring in a mouse contusion SCI model, suppresses GFAP-positive glial scar formation, and promotes axonal regeneration and angiogenesis, culminating in improved locomotor function. Mechanistically, therapeutic outcomes correlate with upregulation of autophagy/mitophagy markers (Beclin-1, Parkin, LC3B), indicating enhanced clearance of damaged mitochondria and neuronal protection. Collectively, Que@MCEu/H offers a promising, multifunctional platform that couples antioxidation, immunomodulation, and mitochondrial protection to facilitate SCI repair and functional recovery.